A total of 26 patients were treated with pergolide mesylate, a semi-synthetic ergot derivative with the property of direct dopamine activity. Of these patients, 18 suffered from late failure of L-dopa, while the remaining 8 had never before been treated with L-dopa. The aim of the trial was to study
β¦ LIBER β¦
Pergolide in Parkinson's disease: time for a change?
β Scribed by Katherine A Grosset; Donald G Grosset
- Book ID
- 117286390
- Publisher
- The Lancet
- Year
- 2004
- Tongue
- English
- Weight
- 57 KB
- Volume
- 363
- Category
- Article
- ISSN
- 0140-6736
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## Abstract The effect of pergolide 25 ΞΌg twice daily on levodopa initiation was assessed in a randomized, placeboβcontrolled, parallel group, doubleβblind multicenter trial in 106 untreated early Parkinson's disease patients. The primary endpoint of mean time until levodopa was 520 days (95% confi