## Abstract The cell‐cycle regulating protein p27^Kip1^ (p27) has dual roles by acting as both a cdk inhibitor and as an assembly factor for different cdk complexes. Loss of p27 has been linked to malignant features in tumours; however, the exact role of p27 deregulation in breast cancer regarding
✦ LIBER ✦
Performance status 1 predicts psychological response in female, but not male, ambulatory cancer patients
✍ Scribed by Koji Taniguchi; Tatsuo Akechi; Shimako Suzuki; Motoyuki Mihara; Yosuke Uchitomi
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 185 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0941-4355
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## Abstract Hypoxia is common in many solid tumours, including breast cancer. Hypoxia triggers the expression of hypoxia inducible factor‐1α (HIF‐1α), and HIF‐1α has been associated with an impaired prognosis in breast cancer and down‐regulation of the oestrogen receptor (ER), potentially affecting