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Performance of a semiautomated papanicolaou smear screening system

✍ Scribed by Sherman, Mark E. ;Schiffman, Mark ;Herrero, Rolando ;Kelly, Deidra ;Bratti, Concepcion ;Mango, Laurie J. ;Alfaro, Mario ;Hutchinson, Martha L. ;Mena, Fernando ;Hildesheim, Allan ;Morales, Jorge ;Greenberg, Mitchell D. ;Balmaceda, Ileana ;Lorincz, Attila T.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 86 KB
Volume: 84
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19981025)84:5<273::aid-cncr2>3.0.co;2-#

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Automated cytology devices have utility in quality assurance applications, but the effectiveness of these devices in primary screening is unknown.

METHODS.

Enrollment smears obtained from 7323 women participating in a population-based study sponsored by the National Cancer Institute were screened manually in Costa Rica and then evaluated independently in the U.S. with the PAPNET system (Neuromedical Systems, Inc., Suffern, NY), a semiautomated, neural network-based device. Smears with abnormal PAPNET images were microscopically rescreened and then diagnosed by a U.S. cytopathologist. ThinPrep slides (Cytyc Corporation, Boxborough, MA), prepared from rinses of the cytologic sampler, and cervigrams (National Testing Laboratories, Fenton, MO) were also evaluated. Women with any abnormal cytologic diagnosis or a positive cervigram were referred for colposcopy with biopsy and definitive therapy if indicated.

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