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Perforin and Tumor Necrosis Factor α in the Pathogenesis of Experimental Allergic Encephalomyelitis: Comparison of Autoantigen Induced and Transferred Disease in Lewis Rats

✍ Scribed by Werner Held; Richard Meyermann; Yufen Qin; Christoph Mueller


Book ID
115621219
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
573 KB
Volume
6
Category
Article
ISSN
0896-8411

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Rats of the Fischer 344 (F344) strain are resistant to experimental allergic encephalomyelitis (EAE) induced by active immunization with guinea pig myelin basic protein (MBP) in complete Freund's adjuvant whereas Lewis (LEW) rats are susceptible even though both strains share the same I-A-like class