Per1 and Per2 gene expression in the rat suprachiasmatic nucleus: circadian profile and the compartment-specific response to light
โ Scribed by L. Yan; S. Takekida; Y. Shigeyoshi; H. Okamura
- Book ID
- 117493073
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 853 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0306-4522
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## Abstract Aging alters circadian components such as the freeโrunning period, the dayโtoโnight activity ratio and photic entrainment in behavioral rhythms, and 2โdeoxyglucose uptakes and neuronal firing in the suprachiasmatic nucleus (SCN). A core clock mechanism in the mouse SCN appears to involv
## Abstract The suprachiasmatic nuclei (SCN) of the hypothalamus contain the master circadian clock in mammals. Nocturnal light pulses that reset the circadian clock also lead to rapid increases in levels of __Per1__ and __Per2__ mRNA in the SCN, suggesting that these genes are involved in the sync