Peptidylglycine-α-Hydroxylating Monooxygenase Generates Two Hydroxylated Products from Its Mechanism-Based Suicide Substrate, 4-Phenyl-3-butenoic Acid †

Probing the Peptidylglycine α-Hydroxylat

Probing the Peptidylglycine α-Hydroxylating Monooxygenase Active Site with Novel 4-Phenyl-3-butenoic Acid Based Inhibitors

✍ Emma Langella; Sébastien Pierre; Wadih Ghattas; Michel Giorgi; Marius Réglier; M 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 838 KB

Specific inhibition of the copper-containing peptidylglycine alpha-hydroxylating monooxygenase (PHM), which catalyzes the post-translational modification of peptides involved in carcinogenesis and tumor progression, constitutes a new approach for combating cancer. We carried out a structure-activity