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Peptidyl Aldehydes as Reversible Covalent Inhibitors of Src Homology 2 Domains †

✍ Scribed by Park, Junguk; Fu, Hua; Pei, Dehua

Book ID
125999304
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
161 KB
Volume
42
Category
Article
ISSN
0006-2960

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## Abstract A mass spectrometric protocol for identifying ligands with a wide range of affinities (3–101 µM) and quantitative spectral analysis for non‐covalent interactions have been developed using Src SH2 as a target. Dissociation constants of five compounds, three with a phospho moiety, one wit