Peptidomimetic design of unusual turns by incorporating flexible and rigid ω-amino acids simultaneously

Design of a novel secondary structure sc

Design of a novel secondary structure scaffolding device: Induction of a reverse turn in tetrapeptides by incorporating a β-amino acid and stereocontrolled free radical α-substitution reactions in peptide motifs

✍ Stephen Hanessian; Hua Yang 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 236 KB

The incorporation of a-substituted t-amino acids into a tetrapeptide motif induces a reverse turn in aprotic solvent systems as revealed by NOESY and ROESY techniques, and by CD spectra. The conformations of these compounds have been studied by mol ecul ar modeling, and further supported by performi