Peptides related to the antigenic determinant block T cell recognition of the native protein as processed by antigen-presenting cells

Contribution of antigen processing to th

Contribution of antigen processing to the recognition of a synthetic peptide antigen by specific T cell hybridomas

✍ Michel Boyer; Zuzana Novak; Arun Fotedar; Bhagirath Singh 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 808 KB

Most antigens recognized by T cells require unfolding or partial degradation (processing) followed by association with Major Histocompatibility Complex (MHC) molecules. We examined the processing requirements for the presentation of antigen to two T cell hybridomas which recognize the alpha-helical