A key step leading to fertilization is the binding of sperm to the egg plasma membrane. When a mammalian sperm reaches the egg plasma membrane, fertilin, an extracellular sperm membrane protein, is believed to bind to an egg plasma membrane receptor mediating fusion. Fertilin is composed of two subu
Peptides corresponding to the second epidermal growth factor-like domain of human blood coagulation factor VII: synthesis, folding and biological activity
✍ Scribed by HUSBYN, METTE ;ÖRNING, LARS ;SAKARIASSEN, KJELL S. ;FISCHER, PETER M.
- Book ID
- 110893627
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 730 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1397-002X
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## Abstract The 45‐residue C‐terminal EGF‐like domain in human blood coagulation factor IX has been synthesized by a 2‐step method to form selectively 3 disulfide bridges. Four out of 6 cysteines are blocked with either trityl or 4‐methyl‐benzyl, and the remaining 2 cysteines are blocked with aceta
Coagulation factor VII bound to its cofactor tissue factor is the physiological initiator of blood coagulation. The interaction between factor VII and tissue factor involves all four of the structural modules found in factor VII, with the most significant contribution coming from the first EGF-like