Peptide/Protein Hybrid Materials: Enhanced Control of Structure and Improved Performance through Conjugation of Biological and Synthetic Polymers
✍ Scribed by Guido W. M. Vandermeulen; Harm-Anton Klok
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 429 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
Summary: The conjugation of peptides/proteins and synthetic polymers is a useful strategy to overcome some of the limitations related to the use of the individual components. This review will highlight two aspects: enhanced structural control at the nanometer level and improved performance, in particular with respect to biomedical applications. In the former case, peptide sequences are mainly used to mediate self‐assembly of synthetic polymers. In the latter case, conjugation of an appropriate synthetic polymer to a pharmaceutically active peptide/protein can, for example, prevent premature enzymatic degradation and enhance blood circulation times, which is therapeutically advantageous.
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