Notwithstanding great advances in the engineering and structural analysis of globular proteins, relatively limited success has been achieved with membrane proteinsdue largely to their intrinsic high insolubility and the concomitant difficulty in obtaining crystals. Progress with de novo synthesis of
β¦ LIBER β¦
PeptideMine - A webserver for the design of peptides for protein-peptide binding studies derived from protein-protein interactomes
β Scribed by Khader Shameer; Lalima L Madan; Shivamurthy Veeranna; Balasubramanian Gopal; Ramanathan Sowdhamini
- Book ID
- 114999273
- Publisher
- BioMed Central
- Year
- 2010
- Tongue
- English
- Weight
- 884 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1471-2105
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A fast and reliable evaluation of the binding energy from a single conformation of a molecular complex is an important practical task. Knowledge-based scoring schemes may not be sufficiently general and transferable, while molecular dynamics or Monte Carlo calculations with explicit solvent are too