## Abstract A cationic peptide, Td3701, which was derived from factor VIII that has affinity with phosphatidylserine (PS), showed efficient transfection ability for cells that express PS on the cell surface. PS is exposed on tumor cell surfaces therefore we have focused on PS as the target molecule
Peptide vector for gene delivery with high affinity for phosphatidylserine
โ Scribed by Shinichi Kuriyama; Yasushi Taguchi; Kanako Nishimura; Kiyoshi Mizuguchi; Kazutoshi Kobayashi; Yoshiki Katayama; Kazutoshi Yanagibashi; Takuro Niidome
- Book ID
- 105360591
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 372 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.768
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## Background: Efficient and non-toxic gene delivery, preferably with non-viral dna vectors readily transferable to clinical practice, is generally regarded as a major limitation for gene therapy. ## Methods: A 31 amino acid, integrin-targeted bifunctional synthetic peptide (polylysine-molossin),