Peptide synthesis. Part 11. A system for continuous flow solid phase peptide synthesis using fluorenylmethoxycarbonyl-amino acid pentafluorophenyl esters
β Scribed by Alison Dryland; Robert C. Sheppard
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 903 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4020
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## Abstract An improved method for the preparation of Merrifield resin esters is presented. This method is rapid, is free of racemization, and is not complicated by a quaternization side reaction. Chloromethylated resin beads, __t__βbutoxycarbonyl amino acid, and potassium __t__βbutoxide are heated
A preparative method for the preparation of large peptides is described. An advantageous theoretical weight of peptide/weight of starting resin ratio (tP w /R w ) of about 0.3 was successfully experimented. The esterification of the first amino acid was realized with a racemization of less than 1%.