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Peptide segment ligation: A new method for synthesis of peptide and protein

✍ Scribed by Yuan Ma; Yufen Zhao

Book ID
105728308
Publisher
Springer
Year
2003
Tongue
English
Weight
424 KB
Volume
48
Category
Article
ISSN
1001-6538

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πŸ“œ SIMILAR VOLUMES

Simple and efficient solid-phase synthes
Simple and efficient solid-phase synthesis of unprotected peptide aldehyde for peptide segment ligation
✍ Dominique LeliΓ¨vre; Hadjila Chabane; AgnΓ¨s Delmas πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 217 KB

We describe an efficient solid-phase synthesis of C-terminal peptide aldehyde. Making use of the stability of the PAM linker towards both acid and base conditions, a pentapeptide was synthesized starting from a PAM resin according to Fmoe/tBu chemistry. The side-chains were deprotected by TFA. The p