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Peptide Nucleic Acids (PNA) in Chemical Biology and Drug Discovery

✍ Scribed by Peter E. Nielsen

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
323 KB
Volume
7
Category
Article
ISSN
1612-1872

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✍ Anne B. Eldrup; Bettina B. Nielsen; Gerald Haaima; Hanne Rasmussen; Jette S. Kas 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 402 KB 👁 1 views

The synthesis of two novel PNA nucleobases derived from 1,8-naphthyridin-2(1H)-one (bT) and benzo[b]-1,8-naphthyridin-2(1H)-one (tT) are reported, together with their incorporation into oligomers of PNA and evaluation as substitutes for thymine. Compound bT is shown to be an effective mimic of the n