Peptide nucleic acids: Cellular delivery and recognition of DNA and RNA targets
β Scribed by David R. Corey
- Book ID
- 106452037
- Publisher
- Springer Netherlands
- Year
- 2005
- Tongue
- English
- Weight
- 101 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1573-3149
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π SIMILAR VOLUMES
Peptide Nucleic Acids (PNAs) are DNA mimics in which the chiral monomer inserted in the middle of the strand is able to induce a strong preference in the helix handedness of a deoxyribose phosphate backbone has been replaced by a pseudo-peptide skeleton composed of N-(2-aminoethyl)-PNA-PNA duplex. T
## Abstract A new series of oxyβpeptide nucleic acids (pyrrolidineβbased oxyβpeptide nucleic acids = POPNAs) of four different stereoisomeric forms (__cis__βL, __cis__βD, __trans__βL, __trans__βD) have been synthesized. To find a favorable stereoisomer of POPNA for hybridization with DNA or RNA, th
Lys-based 'chiral box' Peptide Nucleic Acids (PNAs with three adjacent 2D-Lys-based chiral monomers) have shown unsurpassed specificity in DNA recognition. In this Letter, the binding performances of arginine-based chiral PNAs were evaluated for PNAs containing in the middle part of the strand eithe