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Peptide Nucleic Acid Monomers: A Convenient and Efficient Synthetic Approach to Fmoc/Boc Monomers

✍ Scribed by Browne, Elisse C.; Langford, Steven J.; Abbott, Belinda M.


Book ID
115463945
Publisher
Commonwealth Scientific and Industrial Research Organisation Publishing
Year
2012
Tongue
English
Weight
296 KB
Volume
65
Category
Article
ISSN
0004-9425

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## Abstract A straightforward synthesis of orthogonally protected PNA monomers is described. Protected aminoethylglycine (Aeg) monomers were efficiently prepared by reductive amination of __N__‐Fmoc‐glycinaldehyde with glycine methyl ester and the subsequent acylation of the free amine with __N__‐b