Peptide modulation of allergen-specific immune responses

✍ Scribed by Gerard F Hoyne; Nanna M Kristensen; Hans Yssel; Jonathan R Lamb

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 520 KB
• Volume: 7
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/0952-7915(95)80044-1

✦ Synopsis

In vitro peptide stimulation of allergen-reactive T-helper type 1 and type 0 cells, in the absence of costimulatory signals, induces anergy that is accompanied by the modulation of cell surface phenotype and changes in cytokine production. In experimental animal models, the administration of allergen-derived peptides may result in the downregulation of cytokine and antibody production, which is preceded by transient activation of CD4+ T cells, without the induction of effector immunity. Preliminary results of clinical trials using allergen-derived peptides for desensitization are becoming available and should provide some insight into the efficacy of peptide therapy in man.