Conformational properties of topoisomera
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M. Palumbo; M. Mabilia; A. Pozzan; G. Capranico; S. Tinelli; F. Zunino
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Article
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1994
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John Wiley and Sons
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English
β 527 KB
## Abstract The sequence specificity of topoisomeraseβIIβmediated DNA cleavage, stimulated by 2βmethylβ9βhydroxy ellipticinium and 4β², 5β²,7βtrihydroyflavone (genistein) was investigated by sequencing analysis of DNA cleavage sites and molecular modeling techniques. The former drug exhibits a marked