Agonist-induced T cell receptor down-reg
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Mariolina Salio; Salvatore Valitutti; Antonio Lanzavecchia
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Article
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1997
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John Wiley and Sons
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English
โ 460 KB
T cell receptor (TCR) down-regulation is a consequence of specific receptor engagement and plays an important role in modulating the T cell response. We have investigated the role of protein kinase C (PKC) and protein tyrosine kinases (PTK) in the induction ofTCR down-regulation. We report that the