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Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation

โœ Scribed by Martin F. Bachmann; Annette Oxenius; Daniel E. Speiser; Sanjeev Mariathasan; Hans Hengartner; Rolf M. Zinkernagel; Pamela S. Ohashi


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
1022 KB
Volume
27
Category
Article
ISSN
0014-2980

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Agonist-induced T cell receptor down-reg
โœ Mariolina Salio; Salvatore Valitutti; Antonio Lanzavecchia ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 460 KB

T cell receptor (TCR) down-regulation is a consequence of specific receptor engagement and plays an important role in modulating the T cell response. We have investigated the role of protein kinase C (PKC) and protein tyrosine kinases (PTK) in the induction ofTCR down-regulation. We report that the