Peptide-derived self-assembled monolayers: Assorption of N-stearoyl L-systeine methyl ester on gold
✍ Scribed by Susan L. Dawson; David A. Tirrell
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 174 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0952-3499
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✦ Synopsis
The work reported herein concerns the assembly of N-stearoyl L-cysteine methyl ester [CH 3 (CH 2 ) 16 COCysOMe, 1] on the surface of gold. This compound serves as a simple model of a related polypeptide, which has been designed to adopt a -sheet architecture on metallic and oxide surfaces. We describe the preparation of monolayers of 1, and characterization of these layers via ellipsometry, vibrational spectroscopy and X-ray photoelectron spectroscopy. The results are most consistent with a disordered array of the alkyl chains, in which close packing is frustated by a mismatch in the cross-sectional areas of the cysteinyl ester head group and the stearoyl chains of the thiol. Despite the disorder, the alkyl chains form a hydrophobic surface layer, with an advancing contact angle for water comparable to that observed for octadecanethiol on gold.