Peptide bond formation using an enzyme mimicking approach
β Scribed by Cesare Gennari; Francesco Molinari; Umberto Piarulli
- Book ID
- 103404731
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 277 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The optimized formation of the peptide bond by means of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) has been found to occur rapidly and essentially quantitatively in a one-pot, one-step procedure. This new method is effective for the coupling of a variety of reactive partners, including chiral amin
A novel method for peptide bond formation utilizing amino acid 2-formyl-4-nitrophenylthio ester has been developed. The reaction can be performed in water-containing media and is compatible with various types of amino acid side-chain functional groups. Use of N-methylmaleinimide as an additive is es