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Pentostatin in the treatment of hairy-cell leukemia

✍ Scribed by Michael R Grever; Charles A Doan; Eric H Kraut


Book ID
119614361
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
85 KB
Volume
16
Category
Article
ISSN
1521-6926

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## Abstract ## BACKGROUND. The purine analogs pentostatin and cladribine have revolutionized the treatment of hairy cell leukemia (HCL) with overall responses in greater than 85% of patients and a median progression‐free survival of up to 15 years. They continue to be effective at second‐ and even

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## BACKGROUND. With the introduction of new drugs such as interferon-␣ (IFN) and purine analogs, the management of hairy cell leukemia (HCL) patients has changed. However, pentostatin has been found to produce higher complete remission rates than IFN. The current study was undertaken to investigat