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Penicillin-induced epileptogenesis in immature rat CA3 hippocampal pyramidal cells

✍ Scribed by John W. Swann; Robert J. Brady


Book ID
119100873
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
908 KB
Volume
12
Category
Article
ISSN
0165-3806

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Epileptic discharges were induced by superfusion of rat hippocampal slices with penicillin. Under these conditions the neurons generated paroxysmal depolarization shifts (PDS) after electrical stimulation of Schaffer collaterals. The PDS were followed by large afterhyperpolarizations lasting about 2