Penicillin-cephalosporin conversion X. New synthesis of dithioazetidinones from thiazoline-azetidinones

Penicillin-cephalosporin conversion IV.

Penicillin-cephalosporin conversion IV. Direct synthesis of 3'-thiosubstituted cephalosporins from thiazoline-azetidinones

✍ Sigeru Torii; Hideo Tanaka; Michio Sasaoka; Norio Saitoh; Takashi Siroi; Junzo N 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 183 KB

Direct transformation of thiazoline-azetidinones 2, derived from penicillin G and V, into 3'-thio-substituted cephalosporins 4 has been performed by ring opening of the thiawline moiety with sulfenyl chlorides followed by ring closure with NH 3 in dimethylformamide and simultaneous displacement of t