Penicillin binding protein 2x as a major contributor to intrinsic β-lactam resistance of Streptococcus pneumoniae

Deacylation Kinetics Analysis of Strepto

Deacylation Kinetics Analysis of Streptococcus pneumoniae Penicillin-Binding Protein 2x Mutants Resistant to β-Lactam Antibiotics Using Electrospray Ionization– Mass Spectrometry

✍ Anne Marie Di Guilmi; Nicolas Mouz; Yves Pétillot; Eric Forest; Otto Dideberg; T 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 115 KB

Penicillin-binding proteins (PBPs) catalyze the transpeptidase reaction involved in peptidoglycan synthesis and are covalently inhibited by the ␤-lactam antibiotics. In a previous work we have focused on acylation efficiency measurements of various Streptococcus pneumoniae PBP2x\* mutants to study t