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Penicillin acylase-catalyzed synthesis of pivampicillin: Effect of reaction variables and organic cosolvents

✍ Scribed by Min Gon Kim; Sun Bok Lee


Book ID
113411268
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
933 KB
Volume
1
Category
Article
ISSN
1381-1177

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Penicillin Acylase Catalysed Synthesis o
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## Abstract Penicillin acylase (EC 3.5.1.11) from __Alcaligenes faecalis__, immobilised as a cross‐linked enzyme aggregate (CLEA), catalysed the synthesis of ampicillin in water‐miscible organic solvents at low water concentrations. Below 4% water (v/v) no reaction was observed, showing the crucial