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Penetration of oseltamivir and its active metabolite into the brain after lipopolysaccharide-induced inflammation in mice

✍ Scribed by Shigeru Oshima; Eiichi Nemoto; Mika Kuramochi; Yukiya Saitoh; Daisuke Kobayashi


Book ID
111710215
Publisher
Pharmaceutical Press
Year
2009
Tongue
English
Weight
125 KB
Volume
61
Category
Article
ISSN
2042-7158

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Penetration of pefloxacin into the uroepithelium was studied in 20 patients (10 men and 10 women) receiving a single oral dose of 800 mg. Samples of serum, urine, and uroepithelium were taken 1.8 h (mean) after the dose. Pefloxacin and its active metabolite, norfloxacin, were assayed by liquid chrom