Pelvic urine composition as a determinant of inner medullary solute concentration and urine osmolarity

Low urine osmolarity as a determinant of

Low urine osmolarity as a determinant of cisplatin-induced nephrotoxicity

✍ Emmanuel Polycarpe; Laurent Arnould; Elise Schmitt; Laurence Duvillard; Emmanuel 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 191 KB

## Abstract Cisplatin is widely used in the treatment of human tumors, but it is a nephrotoxic drug. Early pragmatic clinical trials have shown that cisplatin‐induced renal toxicity is greatly reduced through the use of high hydration, a large NaCl supply and mannitol infusion, but the precise mech