✦ LIBER ✦

PELP1: A novel therapeutic target for hormonal cancers

✍ Scribed by Dimple Chakravarty; Rajeshwar Rao Tekmal; Ratna K. Vadlamudi

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 161 KB
Volume: 62
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.287

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Recent studies implicate that the estrogen receptor (ER) coregulator proline‐, glutamic acid‐, and leucine‐rich protein (PELP) 1 as playing critical roles in ER‐genomic, ER‐nongenomic, and ER‐signaling cross talk with growth factor signaling pathways. PELP1 expression is deregulated in hormonal cancers and recent studies further elucidated the molecular mechanisms by which PELP1 regulates hormone therapy response. Although PELP1 is important for normal functions of the ER, the possibility to target ER‐PELP1 axis appears to be an effective strategy for preventing hormonal carcinogenesis and therapy resistance. Thus, PELP1 may be useful as prognostic marker for hormonal cancers and PELP1 signaling may be useful to generate targeted therapeutics to overcome hormonal therapy resistance. © 2009 IUBMB IUBMB Life, 62(3): 163–169, 2010

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