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Pegylated liposomal doxorubicin treatment in recurrent gynecologic cancer patients with renal dysfunction

✍ Scribed by Yanfang Li; Kevin W. Finkel; Wei Hu; Siqing Fu; Jihong Liu; Robert Coleman; John J. Kavanagh

Book ID
113961091
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
163 KB
Volume
106
Category
Article
ISSN
0090-8258

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## Abstract ## BACKGROUND Doxorubicin exhibits high efficacy in malignant glioma cell cultures. Nonetheless, as a standard formulation, doxorubicin has not been used clinically, due to poor penetration of the blood‐brain barrier. Furthermore, doxorubicin is known to induce tumor resistance genes.