Pegylated liposomal doxorubicin in combination with dexamethasone and bortezomib (VMD) or lenalidomide (RMD) in multiple myeloma pretreated patients
β Scribed by Gabriele Buda; Enrico Orciuolo; Sara Galimberti; Matteo Pelosini; Mario Petrini
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 66 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0939-5555
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## Abstract ## BACKGROUND Recently, the authors reported improved time to disease progression (TTP) with a combination of pegylated liposomal doxorubicin (PLD) and bortezomib compared with bortezomib alone in a phase 3 randomized trial in patients with recurrent/refractory multiple myeloma (MM). I
## Abstract ## BACKGROUND Patients with multiple myeloma (MM) have increased bone marrow angiogenesis, a low plasma cell labeling index, and multidrug resistance (the primary cause of chemotherapy failure). MM patients receiving the vincristine, doxorubicin, and dexamethasone (VAD) regimen develop