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PEGylated DOTA-α-MSH analogues for in vivo targeting of melanoma

✍ Scribed by Francisco Silva; Maurício Morais; Paula D. Raposinho; M. Paula C. Campello; João D.G. Correia; António Paulo; Isabel Santos


Book ID
116799568
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
66 KB
Volume
37
Category
Article
ISSN
0969-8051

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Six alpha-MSH(4-10) [Nle-Asp-His-D-Phe-Arg-Trp-Lys-amide] derivatives carrying 2 or 1 or no 2,3-dihydroxy-(2S)-propyl (DHP) groups on the Lys10 amino side chain were coupled to diethylene-triaminopentaacetic acid (DTPA, a chelator for 111In) in monomeric and dimeric forms and tested for their bindin