PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release
✍ Scribed by Narayan Bhattarai; Hassna R. Ramay; Jonathan Gunn; Frederick A. Matsen; Miqin Zhang
- Book ID
- 113690832
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 823 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0168-3659
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📜 SIMILAR VOLUMES
## Abstract **Summary:** PEG‐grafted chitosan was formulated such that its solution undergoes a thermally reversed phase transition from an injectable free‐flowing solution at low temperature to a gel at body temperature. Aqueous solutions of PEG‐grafted chitosan can be prepared at physiological pH
Injectable hydrogels have been studied for potential applications for articular cartilage regeneration. In this study, a thermosensitive chitosan-Pluronic (CP) hydrogel was designed as an injectable cell delivery carrier for cartilage regeneration. The CP conjugate was synthesized by grafting Pluron