✦ LIBER ✦
Pediatric malignant glioma with tubuloreticular inclusions and MYCN amplification. Report of a case with immunohistochemical, ultrastructural, flow cytometric, karyotypic, and southern blot analysis
✍ Scribed by Venita Jay; James Rutka; Laurence E. Becker; Jeremy Squire
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 874 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Background. The authors described unusual pathologic features in a left frontal lobe malignant glioma in a 3l/z-year-old boy. The pathology was similar in the initial excision and two subsequent recurrences at 9 and 11 months and at autopsy, when extensive subarachnoid spread was noted.
Methods. The tumor was studied by conventional histology, immunohistochemistry, flow cytometry, transmission electron microscopy (TEM), immune electron microscopy (IEM), and cytogenetic and Southern blot analysis.
Results. The tumor revealed two different histologic
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