Pediatric Biomedical Informatics: Computer Applications in Pediatric Research

✍ Scribed by John J. Hutton (eds.)

• Publisher: Springer Singapore
• Year: 2016
• Tongue: English
• Leaves: 449
• Series: Translational Bioinformatics 10
• Edition: 2
• Category: Library

✦ Synopsis

The book describes the core resources in informatics necessary to support biomedical research programs and how these can best be integrated with hospital systems to receive clinical information that is necessary to conduct translational research. The focus is on the authors’ recent practical experiences in establishing an informatics infrastructure in a large research-intensive children’s hospital. This book is intended for translational researchers and informaticians in pediatrics, but can also serve as a guide to all institutions facing the challenges of developing and strengthening informatics support for biomedical research. The first section of the book discusses important technical challenges underlying computer-based pediatric research, while subsequent sections discuss informatics applications that support biobanking and a broad range of research programs. Pediatric Biomedical Informatics provides practical insights into the design, implementation, and utilization of informatics infrastructures to optimize care and research to benefit children.

✦ Table of Contents

Front Matter....Pages i-x
Front Matter....Pages 1-1
Electronic Health Records in Pediatrics....Pages 3-26
Protecting Privacy in the Child Health EHR....Pages 27-36
Standards for Interoperability....Pages 37-55
Data Storage and Access Management....Pages 57-77
Institutional Cybersecurity in a Clinical Research Setting....Pages 79-100
Data Governance and Strategies for Data Integration....Pages 101-120
Laboratory Medicine and Biorepositories....Pages 121-139
Front Matter....Pages 141-141
Informatics for Perinatal and Neonatal Research....Pages 143-161
Clinical Decision Support and Alerting Mechanisms....Pages 163-178
Informatics to Support Learning Networks and Distributed Research Networks....Pages 179-201
Natural Language Processing – Overview and History....Pages 203-230
Natural Language Processing: Applications in Pediatric Research....Pages 231-250
Network Analysis and Applications in Pediatric Research....Pages 251-274
Front Matter....Pages 275-275
Genetic Technologies and Causal Variant Discovery....Pages 277-293
Precision Pediatric Genomics: Opportunities and Challenges....Pages 295-312
Bioinformatics and Orphan Diseases....Pages 313-338
Toward Pediatric Precision Medicine: Examples of Genomics-Based Stratification Strategies....Pages 339-361
Application of Genomics to the Study of Human Growth Disorders....Pages 363-384
Systems Biology Approaches for Elucidation of the Transcriptional Regulation of Pulmonary Maturation....Pages 385-419
Functional Genomics-Renal Development and Disease....Pages 421-443
Back Matter....Pages 445-450

✦ Subjects

Biomedicine general;Computational Biology/Bioinformatics;Health Informatics;Biostatistics