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Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease

โœ Scribed by Andreas Koutsoumpas; Dimitrios Polymeros; Zacharias Tsiamoulos; Daniel Smyk; George Karamanolis; Konstantinos Triantafyllou; E.I. Rigopoulou; Alastair Forbes; Diego Vergani; Dimitrios P. Bogdanos; Spiros D. Ladas


Book ID
119223276
Publisher
Oxford University Press
Year
2011
Tongue
English
Weight
561 KB
Volume
5
Category
Article
ISSN
1873-9946

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โœ C. Janneke van der Woude; Pieter Stokkers; Ad A. van Bodegraven; Gert Van Assche ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 274 KB ๐Ÿ‘ 2 views

Background: NI-0401 is a fully human monoclonal antibody, which binds to the CD3 subunit of the T-cell receptor, causing modulation of T-cell activity. We investigated the safety and the ability to modulate the TCR-CD3 complex of NI-0401 in patients with active Crohn's disease (CD). Methods: A doub