Pdgfr-α in 1p/19q LOH oligodendrogliomas

✍ Scribed by Christian Hartmann; Xiudan Xu; Gesine Bartels; Nikola Holtkamp; Isis Atallah Gonzales; Gesche Tallen; Andreas von Deimling

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: French
• Weight: 120 KB
• Volume: 112
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.20525

✦ Synopsis

PDGF-A stimulates O2-A oligodendrocyte precursor cells to proliferate in developing rat brain while differentiation is inhibited, 1 and 2 oligodendroglioma mouse models rely on PDGF-B overexpression. 2,3