✦ LIBER ✦

PDGF-stimulated fibroblast proliferation is enhanced synergistically by receptor-recognized α2-Macroglobulin

✍ Scribed by James C. Bonner; Annette Badgett; Alvaro R. Osornio-Vargas; Maureane Hoffman; Arnold R. Brody

Book ID: 102884646
Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 932 KB
Volume: 145
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041450102

No coin nor oath required. For personal study only.

✦ Synopsis

a-Macroglobulins derived from plasma or secreted by macrophages are plateletderived growth factor (PDGF) binding proteins that compete with cell-surface receptors on fibroblasts for PDGF binding. a,-Macroglobulin (a,M) derived from bovine plasma was tested for its ability to modulate the PDGF-induced proliferation of primary passage rat lung fibroblasts (RLFs) and a human skin fibroblast cell line (CRL 1508). Fibroblasts were grown in 10% fetal bovine serum (FBS) for 24 hr, then washed with serum-free medium before adding serum-free defined medium (SFDM) containing insulin and transferrin. To this medium were added varying concentrations of human plasma-derived AB-PDGF and a,M, alone or in combination. Receptor-recognized a, M was prepared by treatment with methylamine. Both native a, M and the a,Mmethylarnine (a,M-MA) were tested

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