PDGF-like growth factor induces EGF-potentiated phenotypic transformation of normal rat kidney cells in the absence of TGFβ

The transforming growth factor-beta (TGF

The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells

✍ Laia Caja; Esther Bertran; Jean Campbell; Nelson Fausto; Isabel Fabregat 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 515 KB

## Abstract Transforming growth factor‐beta (TGF‐β) mediates several and sometime opposite effects in epithelial cells, inducing growth inhibition, and apoptosis but also promoting an epithelial to mesenchymal transition (EMT) process, which enhances cell migration and invasion. TGF‐β plays relevan