✦ LIBER ✦

PDGF-BB AND IGF-I USE DIFFERENT SIGNALING PATHWAYS TO INDUCE FIBRONECTIN SYNTHESIS IN CULTURED RAT THORACIC AORTIC SMOOTH MUSCLE CELLS

✍ Scribed by Chu S. Lo

Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 127 KB
Volume: 25
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.2000.0622

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✦ Synopsis

Fibronectin, an extracellular matrix protein, acts as an early signal in initiating cell proliferation. Results have indicated that platelet-derived growth factor BB (PDGF-BB) and insulin-like growth factor-I (IGF-I) both enhance fibronectin gene expression. Genistein inhibits PDGF-BB-induced fibronectin levels without inhibiting IGF-I-induced fibronectin levels. It indicates that PDGF-BB and IGF-I utilize separate signaling pathways to induce the synthesis of fibronectin.

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PDGF-BB AND IGF-I USE DIFFERENT SIGNALING PATHWAYS TO INDUCE NaK-ATPase SUBUNITS IN CULTURED RAT THORACIC AORTIC SMOOTH MUSCLE CELLS

✍ Chu S. Lo 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 120 KB

Na + +K + )-adenosine triphosphatase (NaK-ATPase), an ubiquitous membrane transport protein consisting of and subunits, regulates Na + /K + fluxes and maintains many vital physiological functions, including cell growth. Results have indicated that platelet-derived growth factor (PDGF) and insulin-li