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Pd-PEPPSI-IPent: An Active, Sterically Demanding Cross-Coupling Catalyst and Its Application in the Synthesis of Tetra-Ortho-Substituted Biaryls

✍ Scribed by Michael G. Organ; Selçuk Çalimsiz; Mahmoud Sayah; Ka Hou Hoi; Alan J. Lough

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
427 KB
Volume
48
Category
Article
ISSN
0044-8249

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✦ Synopsis

Abstract

Incredible Bulk: A series of N‐heterocyclic carbene catalysts (see picture) were prepared and evaluated in the Suzuki–Miyaura reaction. A variety of sterically encumbered tetra‐ortho‐substituted biaryl products were formed from unreactive aryl chlorides using the isopentyl‐substituted catalyst at temperatures ranging from 65 °C to room temperature. The cyclopentyl‐substituted catalyst was virtually inactive, demonstrating that “flexible bulk” is essential to promote these transformations.magnified image

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ChemInform Abstract: Pd-PEPPSI-IPent: An
ChemInform Abstract: Pd-PEPPSI-IPent: An Active, Sterically Demanding Cross-Coupling Catalyst and Its Application in the Synthesis of Tetra-ortho-Substituted Biaryls.
✍ Michael G. Organ; Selcuk Calimsiz; Mahmoud Sayah; Ka Hou Hoi; Alan J. Lough 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v