A new Pd-catalyzed route to (Β±)-podophyllotoxin is disclosed. The strategy is based on an efficient organoaqueous reaction that diastereoselectively introduces the C-4 hydroxyl group and the furan ring. Further functionalization led to an iododerivative, which was cyclized under optimized conditions
β¦ LIBER β¦
Pd-Catalyzed Route to (.+-.)-Podophyllotoxin Skeleton. Synthesis of the Aryltetralin Derivative.
β Scribed by Lise Charruault; Veronique Michelet; Jean-Pierre Genet
- Book ID
- 101938146
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0931-7597
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Chemoenzymatic and Ring E-Modular Approach to the (-)-Podophyllotoxin Skeleton. Synthesis of 3',4',5'-Tridemethoxy-(-)-podophyllotoxin. -The first ring E deoxygenated derivative (XI) of the antimitotic (-)-podophyllotoxin (XII) is synthesized. The key steps are the introduction of the absolute ste