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Pd-Catalyzed Route to (.+-.)-Podophyllotoxin Skeleton. Synthesis of the Aryltetralin Derivative.

✍ Scribed by Lise Charruault; Veronique Michelet; Jean-Pierre Genet


Book ID
101938146
Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
33
Category
Article
ISSN
0931-7597

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Pd-catalyzed route to (Β±)-podophyllotoxi
✍ Lise Charruault; VΓ©ronique Michelet; Jean-Pierre GenΓͺt πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 96 KB

A new Pd-catalyzed route to (Β±)-podophyllotoxin is disclosed. The strategy is based on an efficient organoaqueous reaction that diastereoselectively introduces the C-4 hydroxyl group and the furan ring. Further functionalization led to an iododerivative, which was cyclized under optimized conditions

ChemInform Abstract: Chemoenzymatic and
✍ D. B. BERKOWITZ; J.-H. MAENG; A. H. DANTZIG; R. L. SHEPARD; B. H. NORMAN πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 36 KB πŸ‘ 2 views

Chemoenzymatic and Ring E-Modular Approach to the (-)-Podophyllotoxin Skeleton. Synthesis of 3',4',5'-Tridemethoxy-(-)-podophyllotoxin. -The first ring E deoxygenated derivative (XI) of the antimitotic (-)-podophyllotoxin (XII) is synthesized. The key steps are the introduction of the absolute ste