Pd-Catalyzed Asymmetric β-Hydride Elimination en Route to Chiral Allenes
✍ Scribed by Crouch, Ian T.; Neff, Robynne K.; Frantz, Doug E.
- Book ID
- 120082932
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 968 KB
- Volume
- 135
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
The asymmetric a-oxylation of the dienolates derived from chiral or, d-or fl, T-unsaturated imide with dibenzyl peroxydicarbonate followed by the Pd(O)catalyzed reactions of the resulting allylic carbonate with various nucleophiles (alkylation, etherification, and amination) is shown to provide the
The dienolates derived from the chiral imides (I) and (IV) undergo asymmetric α-oxylation with dibenzyl peroxydicarbonate to give the (E)-or (Z)-products (III) and (V) highly selectively. Both undergo thermal rearrangements to provide the γ-(S)-or γ-(R)-oxy-substituted derivatives with efficient asy