✦ LIBER ✦

PCILO and CD. Conformational study of sulpiride, a dopamine antagonist

✍ Scribed by Han van de Waterbeemd; Bernard Testa

Publisher: John Wiley and Sons
Year: 1981
Tongue: German
Weight: 285 KB
Volume: 64
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19810640724

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The conformational behaviour of sulpiride has been investigated by the quantum mechanical PCILO method and by CD. measurements. The results indicate the predominance of a folded, intramolecularly H‐bonded conformer, with extended conformers being only slightly less stable. The pharmacological relevance of these results is briefly discussed.

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