Pax6; A pleiotropic player in development
โ Scribed by T. Ian Simpson; David J. Price
- Book ID
- 101705144
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 291 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
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## Background Early in mammalian brain development cell proliferation generates a population of progenitor cells whose subsequent divisions produce increasing numbers of postmitotic neurons. Pax6 affects both processes and it has been suggested that this changing role is due at least in part to cha
Aniridia is an autosomal dominant panocular disorder, characterized by hypoplasia of the iris. It is caused by mutations in the PAX6 gene. This gene encodes a 422-amino acid transcription factor. This protein includes paired and homeo domains, which bind DNA and a proline-serine and threonine-rich P