๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Patterns of recurrence following surgery alone for adenocarcinoma of the colon and rectum

โœ Scribed by Allan W. Cass; Rodney R. Million; William W. Pfaff

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
357 KB
Volume
37
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

Two hundred and eighty patients with previously untreated large bowel adenocarcinoma were retrospectively evaluated following complete primary resection to determine patterns of recurrence. One hundred and five patients (37%) subsequently developed recurrent disease. Sixty percent (63/105) presented with local recurrence alone, 14% (15/105) with concomitant local recurrence and distant metastases, and 26% (27/105) with distant metastases alone. Ninety-two percent of local recurrences developed in structures contiguous to the operative area of the incision. The degree of tumor anaplasia and depth of tumor penetration into the bowel wall influenced the rate of local recurrence. Through 5 years, local recurrence without clinical evidence of distant metastases was the most common cause of death. Plans for adjuvant radiation therapy are discussed.

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Carcinoma of the colon and rectum is one of the most common causes of cancer deaths in the United States. The mortality of patients treated by surgery alone is 55% within 5 years of surgery. Despite efforts to decrease local recurrence and their concomitant problems of pain and disability, a signifi