## Abstract ## BACKGROUND Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell (PC) disorder usually characterized by a benign clinical course. However, in approximately 25% of patients, the disorder has been found to evolve into a multiple myeloma (MM). The mechanism
✦ LIBER ✦
Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic/racial groups: support for genetic factors in pathogenesis
✍ Scribed by Landgren, O; Weiss, B M
- Book ID
- 109886881
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 216 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0887-6924
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## Abstract Multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are characterized cytogenetically by 14q32 rearrangements, −13/13q−, and various trisomies. Occasionally, karyotypic patterns characteristic of myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML)