Patterns of MEPE, DMP1, Phex and Fgf23 expression in growth plate chondrocytes
✍ Scribed by K.A. Staines⁎; V. MacRae; C. Farquharson
- Book ID
- 116323266
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 59 KB
- Volume
- 47
- Category
- Article
- ISSN
- 8756-3282
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## Abstract Growth plate chondrocytes exist in a hypoxic environment where it is recognized that hypoxia‐inducible factor‐1α (HIF‐1α) is essential for their survival. Its regulation of chondrocyte viability may be mediated by the increased expression of vascular endothelial growth factor (VEGF) and
## Abstract The overall goal of the current study was to examine the functional activity of the prolyl hydroxylases (PHDs) in maturing chondrocytes. Herein, we show for the first time that the PHDs are expressed in the maturing zone of the growth plate, and by a chondrocytic cell line. We determine